Table 1.

In vitro susceptibilities of Candida isolates to fluconazole, posaconazole, and voriconazole as determined by the 24-h CLSI and EUCAST broth microdilution methods

Species (no. of isolates)	Antifungal agent	Test method	MIC (μg/ml)		Essential agreement (%)
			Range	Mode
C. albicans (560)	Fluconazole	EUCAST	0.12–32	0.25	99.3
		CLSI	0.12–16	0.12
	Posaconazole	EUCAST	0.015–0.5	0.06	97.9
		CLSI	0.007–0.5	0.03
	Voriconazole	EUCAST	0.007–16	0.015	98.7
		CLSI	0.007–0.25	0.007
C. glabrata (175)	Fluconazole	EUCAST	2–128	8	97.7
		CLSI	1–256	4
	Posaconazole	EUCAST	0.03–16	0.5	99.4
		CLSI	0.06–16	0.5
	Voriconazole	EUCAST	0.03–16	0.25	93.1
		CLSI	0.015–8	0.12
C. parapsilosis (162)	Fluconazole	EUCAST	0.25–128	0.5	97.5
		CLSI	0.12–128	0.5
	Posaconazole	EUCAST	0.015–2	0.06	95.1
		CLSI	0.007–0.25	0.06
	Voriconazole	EUCAST	0.007–2	0.015	96.9
		CLSI	0.007–4	0.007
C. tropicalis (124)	Fluconazole	EUCAST	0.12–16	0.25	98.4
		CLSI	0.12–4	0.12
	Posaconazole	EUCAST	0.015–0.25	0.06	98.4
		CLSI	0.015–0.12	0.06
	Voriconazole	EUCAST	0.007–0.5	0.03	91.1
		CLSI	0.007–0.12	0.015
C. krusei (35)	Fluconazole	EUCAST	16–128	32	97.1
		CLSI	4–32	16
	Posaconazole	EUCAST	0.03–0.25	0.12	94.3
		CLSI	0.03–1	0.25
	Voriconazole	EUCAST	0.12–1	0.25	94.3
		CLSI	0.06–0.25	0.12
Total (1,056)	Fluconazole	EUCAST	0.12–128	0.25	98.6
		CLSI	0.12–256	0.12
	Posaconazole	EUCAST	0.015–16	0.015	97.6
		CLSI	0.007–16	0.03
	Voriconazole	EUCAST	0.007–16	0.015	96.9
		CLSI	0.007–8	0.007