Table 2.
ECVs for fluconazole, posaconazole, and voriconazole and five species of Candida based on the the 24-h CLSI and EUCAST broth microdilution methodsa
| Species | Antifungal agent | Test method | No. tested | MIC mode (μg/ml) | ECV (% ≤ECV) |
|---|---|---|---|---|---|
| C. albicans | Fluconazole | EUCAST | 15,991 | 0.25 | 1 (91.9) |
| CLSI | 8,059 | 0.12 | 0.5 (98.1) | ||
| Posaconazole | EUCAST | NAb | NA | NA | |
| CLSI | 8,059 | 0.015 | 0.06 (98.5) | ||
| Voriconazole | EUCAST | 13,630 | 0.016 | 0.12 (97.3) | |
| CLSI | 8,057 | 0.007 | 0.03 (98.9) | ||
| C. glabrata | Fluconazole | EUCAST | 5,018 | 16 | 32 (89.7) |
| CLSI | 2,240 | 4 | 32 (91.5) | ||
| Posaconazole | EUCAST | NA | NA | NA | |
| CLSI | 2,240 | 0.5 | 2 (96.2) | ||
| Voriconazole | EUCAST | 4,836 | 0.25 | 1 (91.4) | |
| CLSI | 2,240 | 0.06 | 0.5 (90.4) | ||
| C. parapsilosis | Fluconazole | EUCAST | 2,536 | 0.5 | 2 (92.6) |
| CLSI | 2,117 | 0.5 | 2 (93.2) | ||
| Posaconazole | EUCAST | NA | NA | NA | |
| CLSI | 2,116 | 0.06 | 0.25 (99.3) | ||
| Voriconazole | EUCAST | 2,571 | 0.016 | 0.12 (95.3) | |
| CLSI | 2,117 | 0.007 | 0.12 (97.9) | ||
| C. tropicalis | Fluconazole | EUCAST | 2,229 | 0.5 | 2 (93.7) |
| CLSI | 1,771 | 0.25 | 2 (98.4) | ||
| Posaconazole | EUCAST | NA | NA | NA | |
| CLSI | 1,771 | 0.03 | 0.12 (97.6) | ||
| Voriconazole | EUCAST | 2,958 | 0.3 | 0.12 (91.4) | |
| CLSI | 1,771 | 0.015 | 0.06 (97.2) | ||
| C. krusei | Fluconazole | EUCAST | 673 | 32 | 128 (98.4) |
| CLSI | 473 | 16 | 64 (99.8) | ||
| Posaconazole | EUCAST | NA | NA | NA | |
| CLSI | 473 | 0.25 | 0.5 (99.8) | ||
| Voriconazole | EUCAST | 1,289 | 0.25 | 1 (96.8) | |
| CLSI | 472 | 0.12 | 0.5 (99.4) |