Table 3.
CA between the results of the 24-h CLSI and EUCAST broth microdilution methods for fluconazole, posaconazole, and voriconazole and Candida spp. based on ECVs
| Species (no. tested) | Antifungal agent (ECV [μg/ml]) | Test method | No. of isolates (%) with indicated result: |
% CA | % of isolates with discrepant results that were: |
||
|---|---|---|---|---|---|---|---|
| ≤ECV | >ECV | VM | M | ||||
| C. albicans (560) | Fluconazole (0.5) | EUCAST | 551 (98.4) | 9 (1.6) | 98.9 | 0.0 | 1.1 |
| CLSI | 557 (99.5) | 3 (0.5) | |||||
| Posaconazole (0.06) | EUCAST | 540 (96.4) | 20 (3.6) | 93.6 | 3.0 | 3.4 | |
| CLSI | 542 (96.8) | 18 (3.2) | |||||
| Voriconazole (0.03) | EUCAST | 557 (99.6) | 2 (0.4) | 98.6 | 0.0 | 1.4 | |
| CLSI | 558 (99.8) | 1 (0.2) | |||||
| C. glabrata (175) | Fluconazole (32) | EUCAST | 158 (90.3) | 17 (9.7) | 96.0 | 0.6 | 3.4 |
| CLSI | 163 (93.1) | 12 (6.9) | |||||
| Posaconazole (2) | EUCAST | 165 (94.3) | 10 (5.7) | 98.9 | 0.0 | 1.1 | |
| CLSI | 167 (95.4) | 8 (4.6) | |||||
| Voriconazole (0.05) | EUCAST | 148 (84.6) | 27 (15.4) | 93.7 | 0.0 | 6.3 | |
| CLSI | 159 (90.9) | 16 (9.1) | |||||
| C. parapsilosis (162) | Fluconazole (2) | EUCAST | 133 (82.1) | 29 (17.9) | 90.8 | 0.6 | 8.6 |
| CLSI | 146 (90.1) | 16 (9.9) | |||||
| Posaconazole (0.25) | EUCAST | 159 (98.1) | 3 (1.9) | 98.1 | 0.0 | 1.9 | |
| CLSI | 162 (100.0) | 0 (0.0) | |||||
| Voriconazole (0.12) | EUCAST | 152 (93.8) | 10 (6.2) | 98.1 | 0.0 | 1.9 | |
| CLSI | 155 (95.7) | 7 (4.3) | |||||
| C. tropicalis (124) | Fluconazole (2) | EUCAST | 122 (98.4) | 2 (1.6) | 99.2 | 0.0 | 0.8 |
| CLSI | 123 (99.2) | 1 (0.8) | |||||
| Posaconazole (0.12) | EUCAST | 123 (99.2) | 1 (0.8) | 99.2 | 0.0 | 0.8 | |
| CLSI | 124 (100.0) | 0 (0.0) | |||||
| Voriconazole (0.06) | EUCAST | 119 (96.0) | 5 (4.0) | 96.8 | 0.8 | 2.4 | |
| CLSI | 121 (97.6) | 3 (2.4) | |||||
| C. krusei (35) | Fluconazole (64) | EUCAST | 34 (97.1) | 1 (2.9) | 97.1 | 0.0 | 2.9 |
| CLSI | 35 (100.0) | 0 (0.0) | |||||
| Posaconazole (0.5) | EUCAST | 35 (100.0) | 0 (0.0) | 97.1 | 2.9 | 0.0 | |
| CLSI | 34 (97.1) | 1 (2.9) | |||||
| Voriconazole (0.5) | EUCAST | 34 (97.1) | 1 (2.9) | 97.1 | 0.0 | 2.9 | |
| CLSI | 35 (100.0) | 0 (0.0) | |||||