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. 2010 Dec 22;85(5):2126–2137. doi: 10.1128/JVI.01531-10

FIG. 8.

FIG. 8.

Roles of the N-terminal sequence and the loop sequence of IFITM1 in suppressing HIV-1 infection. (A) Illustration of IFITM1 mutants. All mutants lack the C-terminal sequence from amino acids 108 to 125. Red letters indicate the mutated amino acids. The mutated peptide sequence for each location is underlined. The transmembrane domains are shown in boxes. (B) Expression of the IFITM1 mutants in stably transduced SupT1 cell lines upon treatment with doxycycline (500 ng/ml). (C) Replication of HIV-1 in SupT1 cell lines that express IFITM1 mutants. The results shown represent three independent spreading-infection experiments. (D) Effects of IFITM1 mutants on HIV-1 infection in one-cycle infection assays. For details, see the legend to Fig. 3B.