TABLE 2.

Coding envelope mutations observed by full ORF sequencing of transfections and infections with HVR1-deleted HCV recombinants with Core-NS2 of genotypes 1a, 1b, 2b, and 3a^a

^aThe original HCV recombinants are described in greater detail in Table 1. The data were compiled from sequencing multiple transfection/infection ORFs (genotype 1a, 9 ORFs; genotype 1b, 3 ORFs; genotype 2b, 4 ORFs; genotype 3a, 2 ORFs).

b Amino acid change at the amino acid reference positions for HVR1-deleted JFH1 recombinants with genotype-specific Core-NS2 genes. The amino acid reference positions are for H77 reference strain (GenBank accession no. AF0096060). Only coding envelope mutations are shown. A mutation observed in more than one ORF is shown in boldface type. A mutation tested by reverse genetics and found to increase the infectivity of the HVR1-deleted recombinant virus is shown on a gray background. A small solid circle indicates that there was no change for this recombinant.