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Schematic representation of EBNA3C's role in modulating both ING4- and ING5-triggered p53 activity. (A) In response to genotoxic stress, p53 activates its downstream target genes, which subsequently leads to cell cycle arrest and apoptosis. Both ING4 and ING5 trigger a p53-mediated effect on cell proliferation. However, in EBV-positive cells, EBNA3C potentially inhibits both ING4- and ING5-mediated p53 transcriptional activity via displacing the interaction among p53, ING4, and ING5.
