TABLE 1.
Incidence of polytropic virus in mice transplanted with pseudotyping NSCs
4070A infection of NSCs | NSC viral vector | Serum MCF incidencea |
---|---|---|
No | None | 0/6 |
Yes | None | 1/13 |
No | CasE | 0/7 |
Yes | CasE | 2/21 |
No | CasES | 0/8 |
Yes | CasES | 1/15 |
No | hrGFP | 0/7 |
Yes | hrGFP | 0/17 |
Polytropic virus was detected in the sera using a focus assay with a mixture of MAbs specific for polytropic Env proteins, including MAbs 514, 516, and Hy7 (8). The titers for polytropic virus-positive animals were greater than 102 to 103 FFU/ml. The incidence values are expressed as the number of mice with detected virus/total number of mice examined.