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. 2010 Dec 15;85(5):2316–2324. doi: 10.1128/JVI.01476-10

FIG. 2.

FIG. 2.

Magnitude and responder frequency of IL-21-producing HIV-1-specific CD4 and CD8 T cells. PBMC obtained from patients with primary HIV-1 infection (PHI), elite controllers (EC), viremic controllers (VC), and progressors (P) were stimulated with HIV-1 consensus B peptide pools (15-mers overlapping by 11 amino acids) spanning the entirety of the expressed proteome (pooled to represent Gag, Pol, Env, Nef, and the remaining accessory proteins). The magnitudes of CD45RO+ CD4 (A) and CD8 (B) T cells producing IL-21 are shown, with horizontal bars indicating median values. The percentages of patients with HIV-1-specific CD45RO+ CD4 (C) and CD8 (D) T cells producing IL-21 in response to peptides from the indicated proteins are shown. Statistical comparisons were made using the two-tailed Fisher's exact test. *, P = 0.03; **, P = 0.006 (compared to results for P) by Fisher's exact test. #, P < 0.0001 compared to results for each group of HIV-1-seropositive patients by the Mann-Whitney U test.