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Properties of antienterovirus compounds in PV and HCV replicationa
| Compound | CC50 (2 days), μM | Mean (SD) EC50, μM |
SIb (PV) | |
|---|---|---|---|---|
| PV | HCV | |||
| GW5074 | 96 | 4.6 (0.85) | >10 | 21 |
| AN-12-H5 | 78 | 1.1 (0.18) | 0.69 (0.11) | 74 |
| T-00127-HEV1 | >125c | 0.77 (0.10) | >10 | >162 |
| PIK93 | 12 | 0.14 (0.0086) | 1.9 (0.5) | 85 |
Data for GW5074 and AN-12-H5 were adapted in part from reference 3.
SI, selectivity index (ratio of CC50 to EC50).
T-00127-HEV1 showed precipitation at above 125 μM.
