TABLE 1.
Characterization of untreated HIV-2+, untreated HIV-1+, and seronegative cohortsc
| Parameter | Seronegative | Untreated HIV-2 | Untreated HIV-1 |
|---|---|---|---|
| No. (male/female) | 16 (6/10) | 29 (9/20) | 27 (18/9) |
| Median age (range) (yr) | 45 (27-57) | 52 (19-78)# | 39 (23-61) |
| Ethnicity (Caucasian/other) (no.) | 15/1 | 15/14 | 20/7 |
| CD4 T cells/μl (range) | 818 (518-1,312) | 568 (52-1,586)* | 372 (18-1,848)** |
| % CD4 T cells (range) | 43 (34-61) | 28 (7-54)*** | 20 (1-47)*** |
| CD8 T cells/μl (range) | 494 (213-1,109) | 788 (271-1,701)** | 1065 (177-2,996)*** |
| % CD8 T cells (range) | 27 (12-42) | 37 (23-74)*** | 50 (16-69)*** |
| Viremia (range) (RNA copies/ml)a | NA | 200 (200-2.6 × 104)### | 1.4 × 104 (40-4.5 × 106) |
| Proviral DNA (range) (copies/106 PBMC)b | NA | 5 (5-1033) | 54 (5-975) |
a
HIV-2 viremia was below 200 RNA copies/ml (cutoff) in 22 out of 29 patients studied; HIV-1 viremia was below 40 RNA copies/ml (cutoff) in 3 out of 24 patients.
b
Proviral DNA was below 5 copies/106 PBMC (cutoff) in 15 out of the 29 HIV-2-infected patients and in 9 out of 24 HIV-1-infected patients investigated.
c
NA, not applicable. Values are medians, with limits in brackets. Test cutoff value was used to calculate the median if levels were below cutoff. Significance in comparison to seronegative: *, P < 0.05; **, P < 0.01; ***, P < 0.0001. Significance in comparison to HIV-1: #, P < 0.05; ###, P < 0.0001.