TABLE 3.
Correlations between virological parameters and levels of CD4 T cells and immune activation in untreated HIV-2 and HIV-1 infections
| Viremia, DNA, or transcript | Virus type | r; Pa |
|||
|---|---|---|---|---|---|
| % CD4 T cells | CD4 T cells/μl | % HLA-DR+ in CD4 T cells | % HLA-DR+ 38+ in CD8 T cells | ||
| Viremia | HIV-2 | −0.3097; 0.1021 | −0.3943; 0.0343 | 0.5186; 0.0039 | 0.5288; 0.0032 |
| HIV-1 | −0.6120; 0.0009 | −0.5810; 0.0019 | 0.4731; 0.0146 | 0.7140; <0.0001 | |
| Proviral DNA | HIV-2 | 0.0313; 0.8719 | 0.1555; 0.4207 | 0.2281; 0.2339 | 0.1029; 0.5952 |
| HIV-1 | 0.0652; 0.7621 | −0.1019; 0.6358 | 0.0005; 0.9983 | 0.1590; 0.4580 | |
| tat mRNA | HIV-2 | −0.5952; 0.1323 | −0.5238; 0.1966 | 0.6190; 0.1017 | 0.6667; 0.0831 |
| HIV-1 | −0.3737; 0.1150 | −0.3193; 0.1827 | 0.2825; 0.2413 | 0.5404; 0.0169 | |
| gag mRNA | HIV-2 | −0.5728; 0.0130 | −0.3870; 0.1126 | 0.4985; 0.0353 | 0.3189; 0.1971 |
| HIV-1 | 0.2281; 0.3477 | 0.1869; 0.4435 | −0.4018; 0.0882 | −0.4193; 0.0739 | |
a
Test cutoff values were used to calculate the correlations with viremia or proviral DNA, if levels were below the cutoff. Correlations with viral mRNA were calculated using the tat and gag relative quantification values of patients presenting detectable levels of the transcripts (8 and 18 in HIV-2, respectively, and 19 for both tat and gag in HIV-1). Statistically significant correlations are represented in bold.