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. 2010 Dec 8;85(5):2112–2125. doi: 10.1128/JVI.01931-10

FIG. 5.

FIG. 5.

Lung histopathology. (A) Gross pathology and histopathological examination of lung from an NHP in the 5 × 107-PFU i.v. group harvested at necropsy 11 days postinoculation. H and E, pneumonia consisting of interstitial monocytic and granulocytic inflammation (asterix) and edema with areas of pulmonary necrosis (arrow head); IHC, lung exhibits poxviral antigen immunoreactivity centered around areas of necrosis. (B) NHP from the 5 × 106-PFU i.b. group harvested at necropsy 19 days postinoculation. H and E, pneumonia with areas of necrosis (arrow head) and less inflammation than the i.v. group lungs; IHC, strong poxviral antigen immunoreactivity primarily within the cytoplasm of histiocytes (arrow).