TABLE 3.
Comparison of fever development in NHPs infected by the intravenous or intrabronchial route
| Dose (PFU) | i.v. inoculation |
i.b. inoculation |
||||||
|---|---|---|---|---|---|---|---|---|
| No. with fevera/no. challenged | Mean day of fever onsetb (range) | Mean peak temp (°F) | Range of mean peak temp (°F) | No. with fever/no. challenged | Mean day of fever onset (range) | Mean peak temp (°F) | Range of mean peak temp (°F) | |
| 5 × 107 | 5/6 | 2.6 (2-5) | 103.8 | 102.2-104.1 | Not done | |||
| 5 × 106 | 1/6 | 3.0 (NA) | 102.8 | 102.0-103.6 | 3/3 | 6.3 (5-7) | 103.9 | 102.9-104.5 |
| 5 × 105 | 0/3 | NA | 101.9 | 101.7-102.3 | 4/6 | 7.0 (4-11) | 103.5 | 102.1-104.3 |
| 5 × 104 | 0/3 | NA | 101.9 | 101.7-102.3 | 2/3 | 6.0c | 104.2 | 103.7-104.6 |
a
Fever defined as a 2°F increase from the day 0 reading. The mean temperature of all NHPs at day 0 was 101.2°F.
b
NA, not applicable.
c
Both NHPs developed fever on day 6.