TABLE 6.

Cytokine levels indicate a predominantly proinflammatory response

Cytokine/chemokine	Route	Dose (PFU)	Mean day of cytokine peak	Range (days)	Mean peak fold change from day 0	Range (fold change)
IL-1-ra	i.v.	5 × 107	7.0	2-13	4,854	31-25,300
		5 × 106	8.2	2-15	1,855	14-5,553
	i.b.	5 × 106	14.0	7-19	69	3-160
		5 × 105	8.3	4-14	80	2-365
IL-2	i.v.	5 × 107	8.6	6-13	30	10-63
		5 × 106	8.5	3-12	9	2-14
	i.b.	5 × 106	14.0	7-19	18	3-49
		5 × 105	8.2	7-10	20	4-73
IL-6	i.v.	5 × 107	9.6	2-16	1,988	101-9,615
		5 × 106	5.2	3-6	42	11-107
	i.b.	5 × 106	15.7	7-21	3,207	328-9,495
		5 × 105	8.2	7-10	486	82-2,307
IL-8	i.v.	5 × 107	9.2	4-13	73	9-2,798
		5 × 106	10.0	0-16	6	0-10
	i.b.	5 × 106	12.3	9-19	249	2-721
		5 × 105	13.0	8-21	149	2-748
IFN-γ	i.v.	5 × 107	6.7	3-13	400	1-1,167
		5 × 106	3.5	2-5	549	26-1,019
	i.b.	5 × 106	15.6	7-21	442	78-1,042
		5 × 105	7.8	5-10	8,028	44-44,088
MCP-1	i.v.	5 × 107	8.0	5-11	29	7-55
		5 × 106	10.5	8-12	12	4-48
	i.b.	5 × 106	14.0	7-19	30	3-46
		5 × 105	8.7	4-14	441	4-2,307
RANTES	i.v.	5 × 107	5.8	4-10	16	2-49
		5 × 106	7.5	0-16	11	1-25
	i.b.	5 × 106	10.7	9-14	90	2-212
		5 × 105	12.8	8-16	254	5-1,390
GM-CSF	i.v.	5 × 107	10.5	7-35	60	1-297
		5 × 106	8.7	2-16	18	4-45
	i.b.	5 × 106	16.3	9-21	56	10-93
		5 × 105	10.8	8-14	36	2-120
G-CSF	i.v.	5 × 107	9.2	7-13	515	11-2,083
		5 × 106	11.2	8-16	14	2-27
	i.b.	5 × 106	14.7	9-16	724	3-2,161
		5 × 105	11.2	8-16	266	6-1,486
sCD40L	i.v.	5 × 107	7.7	5-13	43	1-98
		5 × 106	9.3	5-16	29	0-104
	i.b.	5 × 106	6.7	0-11	9	1-23
		5 × 105	8.8	8-11	29	15-62