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. 2010 Dec 20;31(5):1066–1075. doi: 10.1128/MCB.00883-10

FIG. 7.

FIG. 7.

Disruption of the β-arrestin 1/ARHGAP21 complex affects AT1AR signaling. (A) Real-time detection of dose-response curves from AT1AR HEK 293 cells treated with angiotensin II as detected using xCELLigence technology. The arrow indicates the time of addition of angiotensin II (Ang II). (B) Determination of IC50s for the angiotensin II response in AT1AR HEK 293 cells using data from panel A. (C) Evaluation of the effects of pretreatment with peptide 842 or a peptide control (Cont.) on the response to angiotensin II treatment (1 h) in AT1AR HEK 293 cells by using xCELLigence technology. Asterisks indicate a significant difference (P < 0.01) from the value for the peptide control.