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. 2011 Jan 19;85(7):3270–3282. doi: 10.1128/JVI.02243-10

FIG. 4.

FIG. 4.

M062 is essential for MYXV pathogenesis in European rabbits. (A) Comparison of in vivo pathogenesis showed that vMyxM062-KO can no longer cause productive infection in rabbits. A total of 1,000 FFU of vMyx-Lau (n = 5), vMyxM062-KO (n = 4), or vMyxM062-Rev (n = 3) were diluted in 100 μl of PBS and inoculated intradermally into the left flank of European rabbits. Another group of rabbits (n = 3) were inoculated with PBS only. The overall physical condition and disease progression were evaluated daily in a clinical score system, and the average daily score was calculated. The error bar in the chart represents ± the SD within each group. (B) MYXV without M062 can no longer cause lethal myxomatosis. The results of the in vivo study described in panel A were analyzed for survival rates among the groups. The daily percentage of survival in each group was plotted to generate the survival curve.