FIG. 3.

Survival rate and clinical score of EV71-infected mouse neonates either untreated or treated with anti-IL-6 antibodies postinfection (PI). Groups of 1-day-old mice were lethally infected with EV71 strain 41 and treated with anti-IL-6 antibodies at 1.33 mg/kg of body weight at 3 days (D3; n = 9) or 6 days (D6; n = 12) post-EV71 challenge. The control groups are either uninfected animals (Naïve; n = 6) or untreated EV71-infected animals (Untreated; n = 8). The survival rates and clinical scores were determined for each mouse group based on daily observation of the animals. Clinical scores were defined as follows: 0, healthy; 1, ruffled hair, hunchbacked; 2, reduced mobility; 3, limb weakness; 4, limb paralysis; and 5, death. *, P < 0.05; **, P < 0.01 (in relation to the untreated group).