FIG. 7.

A schematic representation of the sequence of events thought to occur during the maturation of a transforming MT complex. Starting in the bottom right-hand corner, where MT is synthesized in the cytoplasm on free polysomes, the stages in MT maturation through the ER to exocytic membranes and eventually to the plasma membrane are shown. At each stage, the cellular proteins added to the MT complex are illustrated. A representative mutant that blocks each individual step is also indicated.