TABLE 3.
Inhibitory activity of compound 7 against different viruses
| Family | Virus | Assay type | IC50 (μM)a | CC50 (μM)b | Cells used |
|---|---|---|---|---|---|
| Filovirus | GFP-ZEBOV | GFP | 10 | 55 | Vero E6 |
| MARV | GFP | 12.5 | 55 | Vero E6 | |
| Arenavirus | Tacaribe virus | Neutral red | >32 | 32 | Vero 76 |
| Biodefense-related virus | Rift Valley fever virus | Neutral red | >16 | >16 | Vero 76 |
| VEE virus | Visual | >18 | 18 | Vero | |
| DNA virus | Cowpox virus | CPE | >300 | 300 | HFF |
| Vaccinia virus | CPE | >300 | >300 | HFF | |
| Flavivirus | HCV | PFU | >50 | >50 | IHH |
| Respiratory virus | Influenza A (H1N1) virus California/07/2009 | Neutral red | >25 | 24 | MDCK |
| Influenza (H3N2) virus Brisbane/10/2007 | Neutral red | >33 | 33 | MDCK | |
| SARS virus Urbani | Neutral red | >36 | 36 | Vero 76 |
a
IC50 values were generated for cell culture-grown viruses from the linear portion of the dose response curve.
b
CC50 values were determined from linear portions of the dose-response curve.