TABLE 4.

IC₉₀ values for the benzodiazepine analogs

^aHIV/EBOV-GP was generated by transfection of 293T cells with HIV-l expression vector (pNL4.3.Luc.R-E-) and with EBOV-GP. IC₉₀ values were determined using reordered compounds as different batches from the original vendors or freshly synthesized compounds.

^b293T cells were treated with compound alone. CC₅₀ values were determined from linear portions of the dose-response curve.

^cSI, selectivity index (CC₅₀/IC₉₀).

^dcLogP values were calculated with ChemDraw v12.0.

^eND, not done.