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Permissiveness to prion infection of PrP mutants with an altered glycoform pattern. Human PrP mutations reported to alter the PrPC glycosylation pattern were introduced into the sheep sequence, as indicated (ovine PrP numbering). Immunoblot analysis for PrPC (a) (mock-infected culture, 4F2 antibody) and PrPres (b) (prion-infected cultures at third passage postexposure, Sha31 antibody) is shown. Note that the F210V mutant but not the F210S mutant conferred susceptibility to infection.
