Skip to main content
. 2011 Jan 12;85(7):3239–3249. doi: 10.1128/JVI.02509-10

FIG. 8.

FIG. 8.

The HSV-1 FcγR blocks complement-mediated protection and ADCC. (A) C57BL/6 mice (complement sufficient) were passively immunized with human IgG antibodies to HSV (HuIG) or nonimmune human IgG (NHuIG), and 20 h later they were flank inoculated with 5 × 106 PFU of NS-gE264. (B) C3 knockout mice were passively immunized as described for panel A and flank inoculated with 5 × 105 PFU of NS-gE264. Results in panels A and B are the means and standard deviations of five mice per group. (C and D) C57BL/6 mice were treated i.p. three times with an isotype control MAb (NK intact mice) (C) or anti-NK MAb PK136 (NK-depleted mice) (D), passively immunized with HuIG or NHuIG, and infected with 5 × 105 PFU of NS-gE264. Results in panels C and D are the means and standard deviations of five animals per group. **, P < 0.01; ***, P < 0.001.