Skip to main content
. 2011 Jan 26;85(7):3677–3682. doi: 10.1128/JVI.02541-10

FIG. 2.

FIG. 2.

IN sequence alignment and contribution of potential amino acid residues to resistance to INSTIs. Green indicates residues that when changed can confer resistance to RAL and/or EVG; magenta marks residues known to confer resistance when present at the analogous HIV-1 position; gray indicates residues with unknown effects on potential HIV-1 resistance; red indicates active-site residues; and blue highlights a conserved DNA binding residue (15). Numbers above the alignment indicate HIV-1 amino acid positions; those to the left and right mark positions in the respective IN or transposase protein sequences. Underlining marks the positions of secondary structural elements for HIV-1 (19), SIV (4), RSV (52), and PFV (10) INs and the positions of SB elements from a structure-based alignment with the related Mos1 transposase (37).