TABLE 2.
Hemodynamic analysisa
| Parameter | Mean value ± SD for: |
||
|---|---|---|---|
| F/F;− (n = 11) | F/F;cre (n = 14) | +/+;cre (n = 6) | |
| Age (days) | 66.00 ± 9.75 | 65.29 ± 8.54 | 72.00 ± 12.00 |
| BW (g) | 28.64 ± 3.91 | 28.93 ± 2.53 | 26.83 ± 3.87 |
| HW (mg)b,c | 127.00 ± 15.84 | 156.43 ± 16.02 | 129.17 ± 14.82 |
| HW/TL (mg/mm)b,c | 6.51 ± 0.74 | 8.15 ± 0.81 | 6.69 ± 0.78 |
| HR (bpm) | 522.71 ± 16.12 | 532.68 ± 19.68 | 505.10 ± 34.18 |
| ESP (mm Hg) | 104.32 ± 10.30 | 105.20 ± 11.55 | 97.19 ± 6.56 |
| EDP (mm Hg) | 1.83 ± 1.16 | 3.22 ± 4.02 | 2.27 ± 0.58 |
| CO (ml/min) | 10.76 ± 1.93 | 11.36 ± 2.25 | 8.70 ± 3.25 |
| dP/dtmax (mm Hg/s) | 10,573 ± 1,871 | 9,507 ± 2,110 | 9,000 ± 2,234 |
| dP/dtmin (mm Hg/s) | −9,758 ± 1,490 | −8,915 ± 2,044 | −8,212 ± 1,195 |
| PRSW (mm Hg) | 60.72 ± 10.29 | 66.23 ± 16.48 | 66.06 ± 6.90 |
| dP/dtEDV (mmHg/s·μl) | 263.65 ± 114.15 | 254.96 ± 65.29 | 359.78 ± 72.13 |
| τG (ms) | 9.73 ± 1.45 | 12.02 ± 6.02 | 12.18 ± 3.81 |
a
BW, body weight; HW, heart weight; TL, tibia length; HR, heart rate in beats per minute (bpm); ESP, end-systolic pressure; EDP, end-diastolic pressure; CO, cardiac output; dP/dt, peak rate of pressure increment (maximum or minimum); PRSW, preload recruitable stroke work; dP/dtEDV, dP/dt-EDV relationship; τG, relaxation time constant (tau) calculated by the Glantz equation.
b
There was significant difference between the means for F/F;− and F/F;cre groups at the 0.05 level according to ANOVA followed by the Bonferroni post hoc test.
c
There was significant difference between the means for +/+;cre and F/F;cre groups at the 0.05 level according to ANOVA followed by the Bonferroni post hoc test.