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Inhibition of SFK activity prevents Akt activation during HSV infection. HEL fibroblasts were mock infected or infected with HSV-1 KOS. At 11 h postinfection, the SFK inhibitor PP2 was added at a concentration of 10, 20, and 30 μM, and the inactive PP2 analogue PP3 was added at a 30 μM concentration. Cell lysates were collected at 16 hpi and analyzed by Western blotting using the indicated antibodies.
