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. 2011 Jan 5;85(6):2818–2827. doi: 10.1128/JVI.01969-10

FIG. 6.

FIG. 6.

AG879 and A9 inhibit virus release via FPPS. (A) Determination of infectious viruses associated with membranes or released to the supernatants. A549 cells were infected with A/WSN (MOI of 2) for 8 h and treated with either DMSO or compound for 15, 30, 45, and 60 min. Titers of infectious virus in the supernatants and in the cell lysates were determined. (B) FPPS overexpression fully restored the block of virus release by AG879 and A9. A virus release assay similar to that described for panel A was conducted in cells that had been transfected with empty vector or FPPS expression vector. Results shown are the averages from at least three independent experiments. Error bars indicate SD. Statistical analysis was conducted with Student's t test (**, P < 0.01; ***, P < 0.001; ****, P < 0.0001).