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Fecal IgA responses to HuNoV vaccine. Fecal samples were collected from all mice in each group weekly. Samples were diluted in PBS, vortexed, and clarified by centrifugation, and HuNoV-specific and total IgA antibodies were determined by ELISA. The ratio between HuNoV-specific IgA and total IgA was calculated for each mouse. Data are expressed as the average titer of IgA-positive mice ± the standard deviation.
