TABLE 1.

Predicted open reading frames of RHVP^a

Open reading frame	Genome location (bp)	Coding strand	Size (aa)	% amino acid identity with indicated virus			Possible function
				γHV68	KSHV	HVS
R1	236-697	L	153				Similar to that of MHC class I
R2	639-932	L	97				Similar to that of MHC class I
R3	1000-1383	L	127				Similar to that of MHC class I
R4	2769-3014	L	81
R5	6552-8027	L	491				Ig domain-containing protein
R6	8175-8582	L	135				Similar to that of IL-4/IL-13
ORF 4a	9438-10589	R	383	27	15	26	Complement regulatory protein
R7	10913-12229	L	438				Ig domain-containing protein
R8	12677-13183	R	168				C-type lectin-like protein
R9	14271-14738	R	155
R10	14723-15001	R	92
R11	15403-16266	R	287			18	Similar to that of HVS ORF 14 and MMTV superantigen
ORF 4b	16391-17554	R	387	23	16	25	Complement regulatory protein
ORF 6	17724-21074	R	1,116	47	42	43	Single-stranded DNA binding protein
ORF 7	21077-23041	R	654	40	33	32	Transport protein
ORF 8	23050-25569	R	839	63	51	46	Glycoprotein B
ORF 9	25753-28812	R	1,019	61	54	55	DNA polymerase
ORF 10	28805-30064	R	419	20	19	18
ORF 11	30036-31175	R	379	28	22	20
R12	31220-31996	L	258	15	10		Similar to that of K3 (E3 ubiquitin ligase)
ORF 17	34959-36587	L	542	36	32	36	Capsid protein
ORF 18	36586-37359	R	257	38	40	40
ORF 19	37356-38948	L	530	42	36	36	Tegument protein
ORF 20	38671-39519	L	282	29	22	27
ORF 21	39518-41251	R	577	25	21	20	Thymidine kinase
ORF 22	41272-43452	R	726	40	29	28	Glycoprotein H
ORF 23	43441-44583	L	380	36	28	16
ORF 24	44602-46695	L	697	49	40	41
ORF 25	46706-50830	R	1,374	59	54	55	Major capsid protein
ORF 26	50834-51784	R	316	49	44	45	Capsid protein
ORF 27	51787-52575	R	262	26	0	7
R13	52618-52854	R	78
ORF 29b	52866-53915	L	349	58	53	27	Cleavage and/or packaging protein
ORF 30	53984-54223	R	79	37	32	29
ORF 31	54184-54786	R	200	44	32	32
ORF 32	54768-56087	R	439	25	23	22	Viral DNA cleavage or packaging protein
ORF 33	56071-57054	R	327	45	29	33
ORF 29a	57008-57952	L	314	42	36	17	Cleavage and/or packaging protein
ORF 34	57951-58958	R	335	38	28	33
ORF 35	58873-59370	R	165	29	21	24
ORF 36	59297-60607	R	436	27	22	24	Kinase
ORF 37	60604-62055	R	483	54	40	44	Alkaline exonuclease
ORF 38	62010-62243	R	77	36	23	18
ORF 39	62249-63400	L	383	60	42	45	Glycoprotein M
ORF 40	63478-65340	R	620	28	18	18	Helicase-primase
ORF 42	65332-66105	L	257	43	29	35
ORF 43	65990-67840	L	616	52	42	45	Capsid protein
ORF 44	67776-70115	R	779	57	52	54	Helicase
ORF 45	70134-70811	L	225	37	11	20
ORF 46	70828-71577	L	249	59	51	53	Uracil DNA glycosidase
ORF 47	71562-72026	L	154	23	22	23	Glycoprotein L
ORF 48	72630-73556	L	308	19	13	8
ORF 49	73761-74603	L	280	25	17	16
ORF 50	74655-76640	R	661	19	17	14	Transcriptional activator; Rta homolog
R14	76918-78372	R	484	24			Similar to that of γHV68 M7 (glycoprotein 150)
ORF 52	78415-78831	L	138	42	30	23
ORF 53	78903-79154	L	83	53	27	33
ORF 54	79256-80218	R	320	35	26	27	dUTPase
ORF 55	80240-80812	L	190	48	32	40
ORF 56	80811-83288	R	825	43	36	37	DNA replication protein
ORF 57	83584-84735	R	383	16	15	24
ORF 58	84794-85831	L	345	29	21	22
ORF 59	85837-87102	L	421	29	23	21	DNA replication protein
ORF 60	87222-88145	L	307	62	57	57	Ribonucleotide reductase, small subunit
ORF 61	88180-90498	L	772	49	44	46	Ribonucleotide reductase, large subunit
ORF 62	90507-91496	L	329	34	32	26	Assembly or DNA maturation protein
ORF 63	91507-94245	R	912	29	20	23	Tegument protein
ORF 64	94223-101740	R	2,505	31	24	26	Tegument protein
R15	101750-102325	L	191
ORF 66	102334-103554	L	406	41	28	32
ORF 67	103520-104260	L	246	48	35	44	Tegument protein
ORF 67a	104247-104498	L	83
ORF 68	104549-105919	R	456	38	27	33
ORF 69	105924-106814	R	296	53	35	36
ORF 72	108475-109221	L	248	21	23	20	Cyclin D homolog
R16	109298-109816	R	172	21			vBcl-2 homolog; inhibitor of apoptosis
ORF 73	109832-110716	L	294	20	5	13	LANA homolog
ORF 74	110864-111886	R	340	27	22	18	G protein-coupled receptor
ORF 75b	111883-115824	L	1,313	35	26	26	Tegument protein/FGARAT
ORF 75a	116019-119936	L	1,305	29	25	25	Tegument protein/FGARAT
R17	120546-121865	R	439
R18	122524-123879	R	451				Ig domain-containing protein

^aAbbreviations: L, left; R, right; FGARAT, N-formylglycinamide ribotide amidotransferase.