FIG. 1.

Schematic structure of E8∧E2C. E8∧E2C consists of the small E8 part and the E2C domain, which is comprised of a less conserved “hinge” (H) region and the highly conserved DNA binding domain (DBD). The nucleotide positions for the E8 ATG and the splice donor sites and the splice acceptor and the stop codon for the E2 gene are indicated. Below are the amino acid sequences of the respective E8 parts. Conserved residues are shown in gray. The conserved KWK motif that is responsible for repression activity of the 31 E8∧E2C protein is underlined.