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Percentages of Gag-specific CD8+ and CD4+ T cells expressing interferon (IFN) γ and interleukin (IL) 2 in peripheral blood mononuclear cells (PBMCs). RGV, raltegravir (red); PBO, placebo (blue). Thin lines represent raw data for each subject; thick lines, estimated mean values over time from generalized estimating equations for each group. Raltegravir intensification had no effect on Gag-specific IFN-γ+IL2+CD8+ (A) (P = .19) or IFN-γ+IL2+CD4+ (B) (P = .80) T cell responses in PBMCs.
