Table 3.
Relationship of Multiple HPV Infections with Risk of CIN2+ or HSIL+
| CIN2+ |
HSIL+ |
||||
| No. of women | No. (%) | OR (95% CI) a | No. (%) | OR (95% CI) a | |
| Single HPV | 1409 | 25 (1.8) | 1.00 | 113 (8.0) | 1.00 |
| Multiple HPV | 1070 | 21 (2.0) | 1.12 (.62–2.04) | 112 (10.5) | 1.34 (1.02–1.78) |
| HPV 16 | |||||
| Single | 170 | 7 (4.1) | 1.00 | 29 (17.2) | 1.00 |
| Multiple | 318 | 15 (4.7) | 1.15 (.46–2.88) b | 46 (14.6) | 0.84 (.49–1.42) |
| Non HPV-16 | |||||
| Single | 1239 | 18 (1.5) | 1.00 | 84 (6.8) | 1.00 |
| Multiple | 752 | 6 (.8) | 0.50 (.19–1.31) | 66 (8.8) | 1.32 (.84–1.96) |
| HPV 18 | |||||
| Single | 55 | 1 (1.8) | 1.00 | 8 (14.5) | 1.00 |
| Multiple | 133 | 2 (1.5) | 0.82 (.07–9.28) b | 21 (15.8) | 1.26 (.49–3.21) |
| Oncogenic types | |||||
| Single | 1310 | 24 (1.8) | 1.00 | 123 (9.4) | 1.00 |
| Multiple | 673 | 21 (3.1) | 1.74 (.95–3.19) | 90 (13.4) | 1.48 (1.10–1.99) |
| Oncogenic types excluding | |||||
| HPV16 | 1082 | 17 (1.6) | 1.00 | 91 (8.4) | 1.00 |
| Single | 316 | 3 (.9) | 0.49 (.13–1.80) | 35 (11.1) | 1.37 (.90–2.08) |
| Multiple | |||||
| α9 species | |||||
| Single | 1004 | 25 (2.5) | 1.00 | 117 (11.7) | 1.00 |
| Multiple | 241 | 13 (5.4) | 2.28 (1.13–4.62) | 43 (18.1) | 1.64 (1.11–2.42) |
| α7 species | |||||
| Single | 650 | 13 (2.0) | N/A | 64 (9.9) | 1.00 |
| Multiple | 71 | 0 (.0) | 8 (11.3) | 1.02 (.46–2.62) | |
NOTE. aOdds ratios were adjusted for age, lifetime number of sex partners, number of pregnancies, and smoking
b
These odds ratios were not adjusted for any factors owing to small sample sizes