Table 3.
Univariate and Multivariate Analyses of Factors Associated With Survival in 65 Patients Who Underwent at Least the First Stage of Two-Stage Liver Resection
| Factor | No. of Patients | 5-Year Survival (%) | Univariate Analysis P | Multivariate Analysis P | HR | 95% CI |
|---|---|---|---|---|---|---|
| Primary tumor | .55 | |||||
| Rectal | 18 | 48 | ||||
| Colon | 47 | 52 | ||||
| Node | .4 | |||||
| Positive | 47 | 42 | ||||
| Negative | 12 | 65 | ||||
| Unknown | 6 | 75 | ||||
| CLM | .1 | .9 | ||||
| Synchronous | 52 | 58 | ||||
| Metachronous | 13 | 22 | ||||
| Total number of CLM | .05 | .18 | ||||
| ≤ 7 | 41 | 65 | ||||
| > 7 | 24 | 26 | ||||
| Size of CLM, cm | .3 | |||||
| ≤ 5 | 45 | 58 | ||||
| > 5 | 20 | 31 | ||||
| Preoperative chemotherapy regimen | .3 | |||||
| Fluorouracil + irinotecan | 19 | 59 | ||||
| Fluorouracil + oxaliplatin | 46 | 48 | ||||
| Bevacizumab | .9 | |||||
| No | 17 | 50 | ||||
| Yes | 48 | 53 | ||||
| Preoperative chemotherapy duration, months | .1 | .7 | ||||
| ≤ 3 | 43 | 65 | ||||
| > 3 | 22 | 15 | ||||
| CEA plasma level, ng/dL | .3 | |||||
| ≤ 200 | 5 | 0 | ||||
| > 200 | 60 | 54 | ||||
| No. of lesions resected during first stage | .6 | |||||
| 1 | 29 | 54 | ||||
| Multiple | 36 | 46 | ||||
| Major postoperative complication after first or second resection | .1 | .04 | 3.1 | 1.1 to 9.2 | ||
| Yes | 14 | 55 | ||||
| No | 51 | 33 | ||||
| Two-stage resection | < .001 | .001 | 7.2 | 2.4 to 22.4 | ||
| Noncompletion | 18 | 64 | ||||
| Completion | 47 | 13 |
Abbreviations: HR, hazard ratio; CLM, colorectal liver metastases; CEA, carcinoembryonic antigen.