Table 6.

Chemotherapy Regimens for Low-Risk Gestational Trophoblastic Neoplasia

Chemotherapy Regimen	Primary Remission Rate (%)		Reference
	Current Study	Literature
Methotrexate 0.4 mg/kg/d (max 25 mg/kg/d) IV or IM for 5 days; repeat every 2 weeks	—	60-89	Lurain et al,2 Roberts et al,3 Soper et al4
Methotrexate 30-50 mg/m2 IM weekly	53	74-81	Homesley et al,12 Homesley et al13
Methotrexate 1 mg/kg IM days 1, 3, 5, 7; folinic acid 0.1 mg/kg IM days 2, 4, 6, 8; repeat every 15-18 days	—	73-84	Elit et al,5 Smith et al11
Dactinomycin 1.25 mg/m2 IV every 2 weeks	70	94	Petrilli et al7

Abbreviations: IV, intravenously; IM, intramuscularly.