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. 2011 Mar 18;6:9. doi: 10.1186/1749-8104-6-9

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Copyright ©2011 Manuel et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Foxg1^-/-mutant cells are underrepresented in the telencephalon of Foxg1^+/+;Tg^-↔Foxg1^-/-;Tg⁺chimeras. (A-D) Coronal sections through the thalamus (A,B) and the ventral telencephalon (C,D) of E12.5 Foxg1^+/+;Tg^-↔Foxg1^+/+;Tg⁺control (A,C) and Foxg1^+/+;Tg^-↔Foxg1^-/-;Tg⁺experimental chimeras (B,D) showing Tg⁺cells (labelled with dark dots) derived from the ES cells. (D) Very few Tg⁺cells (arrowheads) are observed in the ventral telencephalon of experimental chimeras. Scale bar: 50 μm. (E) Ratios of observed/expected contributions of Tg⁺cells in the dorsal thalamus, the hippocampus, the cortex and the ventral telencephalon of control (Foxg1^+/+;Tg^-↔Foxg1^+/+;Tg⁺) and experimental (Foxg1^+/+;Tg^-↔Foxg1^-/-;Tg⁺) chimeras. Tg⁺cells are significantly underrepresented in the telencephalon of mutant chimeras (mean ± s.e.m, n = 3 embryos of each genotype; Student's t-test, P < 0.05).