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. 2011 Mar 18;6:9. doi: 10.1186/1749-8104-6-9

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Copyright ©2011 Manuel et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Foxg1^-/-cells display a cell autonomous proliferation defect. (A) Coronal section through the telencephalon of an E12.5 Foxg1^+/+;Tg^-↔Foxg1^-/-;Tg⁺chimera showing Tg⁺cells (labelled with dark dots) and BrdU⁺cells (with brown nuclei). Clusters of BrdU^-Tg⁺cells are present among BrdU⁺Tg^-and Tg⁺progenitors. Scale bar: 50 μm. (B) Percentages of Tg⁺cells in S-phase in the dorsal and ventral telencephalon, but not the dorsal thalamus, of experimental chimeras are significantly lower than the percentages of Tg^-cells in S-phase (mean ± s.e.m, n = 3 embryos of each genotype; Student's t-test, P < 0.05).