Figure 2.

Schematic illustration of the experimental in vivo approach and the incidence of bleedings in APPPS1 transgenic mice. (A) We immunized T-GFP mice with Aβ42 and adoptively transferred these isolated T cells via the tail vein into transgenic or control mice. After a recovery period of one week, a cranial window surgery with dura removal and antibody application of either antibody 10D5 against Aβ or control antibody 16D5 against human tau was performed. Brains were analyzed postmortem 3 to 4 days after passive immunization. (B) In contrast to wildtype mice passively immunized (left image) or APPPS1 transgenic mice immunized with a control antibody against human tau (right image) transgenic mice immunized with anti Aβ antibody developed acute hematomas on both hemispheres as indicated by black arrows (image in the middle).