Figure 4.

Increase in number of acute hematomas following passive immunization. (A-H) Evidence of acute hematomas was assessed in H&E-stained sections confirming the occurrence of acute bleedings in all animals used in this study. (G) The black arrow indicates a significant hemorrhage in T cell transferred mice following IgG αAβ treatment. (B-H) Panels are a higher magnification of the cortical area shown in (A-G). (I) Quantification of acute hemorrhages in the different groups revealed a threefold increase in APPPS1 transgenic mice that have received Aβ primed T cells and were passively immunized. Scale bars, 100 μm (A,C,E,G), 50 μm (B,D,F,H).