Table 1. PSAAP algorithm performance of predicted phenotypes using curated RET mutations.

	PSAAP Prediction a	MutPred Predictionb	PolyPhen Predictionc	PMut Predictiond	SIFT Predictione
Sensitivity	0.938	0.767	0.597	0.783	0.816
Specificity	0.867	0.823	0.920	0.591	0.821
Precision	0.883	0.843	0.541	0.723	0.779

^aPrimary Sequence Amino Acid Properties (PSAAP) algorithm.

^bAnalyzed with default settings at http://mutdb.org/mutpred.

^cAnalyzed with default settings at http://genetics.bwh.harvard.edu/pph.

^dAnalyzed with default settings at http://mmb.pcb.ub.es/PMut.

^eAnalyzed with default settings at http://sift.jcvi.org.