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. 2011 Mar 30;6(3):e18446. doi: 10.1371/journal.pone.0018446

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Heidt et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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In vivo SPECT-CT single (A, B) and fused (C) images after injury of the right carotid artery (right side) and incubation with ¹¹¹In-labeled LIBS. CT angiogram of the neck region enhanced with iodinated contrast (Imeron 350) provides vessel contrast for anatomical detail of the carotid arteries (A, R = right carotid vessel, L = left carotid vessel); three-dimensional reconstruction of the CT-angiogram (D). SPECT imaging of the same neck region after incubation with ¹¹¹In-LIBS depicts a co-localized peak of ¹¹¹In-uptake (kBq/voxel). Three-dimensional overlay of CT data (D) with SPECT signal allows the correlation of the peak uptake to the area of the injured carotid artery (E) Movies of the three-dimensionally rendered images are provided as supporting information (Movie S1, Movie S2).