Table 2. Factors predicted SVR to Peg-IFN/RBV treatment in genotype I chronic hepatitis C patients by univariate and multivariate Logistic regression analysis.
Baseline Predictors | Odds Ratio | 95% CI | p value | |
Univariable | Age (years old) | 0.97 | 0.95–1.00 | 0.064 |
Baseline Viral Load | 3.68 | 1.89–7.19 | <0.001 | |
Fibrosis stage (Metavir) | 2.06 | 1.11–3.83 | 0.002 | |
BMI (Kg/m2) | 0.92 | 0.83–1.00 | 0.060 | |
ALT (IU/L) | 1.00 | 0.99–1.01 | 0.090 | |
GGT (IU/L) | 1.00 | 0.99–1.00 | 0.109 | |
rs12979860 | 4.90 | 1.84–13.03 | 0.001 | |
rs8099917 | 4.25 | 1.66–10.92 | 0.003 | |
rs12980275 | 3.84 | 1.48–9.99 | 0.006 | |
rs8105790 | 4.25 | 1.66–10.92 | 0.003 | |
rs7248668 | 3.84 | 1.48–9.99 | 0.006 | |
rs10853728 | 1.41 | 0.75–2.66 | 0.285 | |
Multivariable | Age (years old) | 0.96 | 0.93–0.99 | 0.012 |
Baseline Viral Load | ||||
≥0.4×106 IU/ml | 1 | |||
<0.4×106 IU/ml | 4.65 | 2.23–9.66 | <0.001 | |
rs12979860 | ||||
CT/TT genotype | 1 | |||
CC genotype | 7.74 | 2.55–23.53 | <0.001 |
UV: univariate logistic regression analysis. MV: multivariate logistic regression analysis.
OR: odds ratio; CI: confidence interval. Fibrosis stage: Metavir scoring system.