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. 2011 Mar 30;6(3):e18322. doi: 10.1371/journal.pone.0018322

Table 2. Factors predicted SVR to Peg-IFN/RBV treatment in genotype I chronic hepatitis C patients by univariate and multivariate Logistic regression analysis.

Baseline Predictors Odds Ratio 95% CI p value
Univariable Age (years old) 0.97 0.95–1.00 0.064
Baseline Viral Load 3.68 1.89–7.19 <0.001
Fibrosis stage (Metavir) 2.06 1.11–3.83 0.002
BMI (Kg/m2) 0.92 0.83–1.00 0.060
ALT (IU/L) 1.00 0.99–1.01 0.090
GGT (IU/L) 1.00 0.99–1.00 0.109
rs12979860 4.90 1.84–13.03 0.001
rs8099917 4.25 1.66–10.92 0.003
rs12980275 3.84 1.48–9.99 0.006
rs8105790 4.25 1.66–10.92 0.003
rs7248668 3.84 1.48–9.99 0.006
rs10853728 1.41 0.75–2.66 0.285
Multivariable Age (years old) 0.96 0.93–0.99 0.012
Baseline Viral Load
≥0.4×106 IU/ml 1
<0.4×106 IU/ml 4.65 2.23–9.66 <0.001
rs12979860
CT/TT genotype 1
CC genotype 7.74 2.55–23.53 <0.001

UV: univariate logistic regression analysis. MV: multivariate logistic regression analysis.

OR: odds ratio; CI: confidence interval. Fibrosis stage: Metavir scoring system.