Figure 3.

PSAPP/CD45^−/− mice have an inflammatory microglial phenotype. a, Mouse brain sections from 8-month-old PSAPP/CD45 or PSAPP/CD45^−/− mice were double-labeled with Iba1 antibody and Congo red. b, c, The microglial proinflammatory cytokines TNF-α and IL-1β were quantified in brain homogenates from both PSAPP/CD45 and PSAPP/CD45^−/− mice at 4 (b) and 8 (c) months of age by ELISA. Data are represented as mean ± SD (n = 8 female mice per group) for each cytokine (picograms per milligrams of protein). **p < 0.01.