Figure 1.

Nucleotide and deduced amino acid sequences of a cDNA clone encoding the rat nAChR α10 subunit. The deduced amino acid sequence is shown above the nucleotide sequence. Amino acids are presented as the standard single-letter code. Functional domains are underlined and include a possible signal peptide and four putative transmembrane regions. Filled circles (●) are placed above extracellular cysteine residues that are conserved in nAChR agonist-binding (or α-type) subunits. The calculated molecular mass of the mature nonglycosylated form of the rat α10 protein is 47,127 Da. Intron positions are indicated by an arrowhead, and the asterisk marks the translation termination codon.