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. Author manuscript; available in PMC: 2012 Apr 5.

Published in final edited form as: Biochemistry. 2011 Mar 7;50(13):2499–2505. doi: 10.1021/bi101722b

Comparison of the time dependence of rat MAO A and MAO B inhibition by ParSL-2 and ParSL-3 in intact and in broken rat liver mitochondria, respectively. (A) intact mitochondria, substrate: serotonin; (B) intact mitochondria, substrate: 3-AmMePy; (C) broken mitochondria, substrate: serotonin; (D) broken mitochondria, substrate: 3-AmMePy. ParSL-2 (or ParSL-3) untreated intact mitochondria and broken mitochondria are shown with empty squares (□). 1mM ParSL-2 and 1 mM ParSL-3 treated mitochondria (intact or broken) are shown with filled circles (●) and filled triangles (▲), respectively. The specific activity of rat liver mitochondria is 0.44 mU/mg (substrate: serotonin) and 1.56 mU/mg (substrate: 3-AmMePy), respectively.

Comparison of the time dependence of rat MAO A and MAO B inhibition by ParSL-2 and ParSL-3 in intact and in broken rat liver mitochondria, respectively. (A) intact mitochondria, substrate: serotonin; (B) intact mitochondria, substrate: 3-AmMePy; (C) broken mitochondria, substrate: serotonin; (D) broken mitochondria, substrate: 3-AmMePy. ParSL-2 (or ParSL-3) untreated intact mitochondria and broken mitochondria are shown with empty squares (□). 1mM ParSL-2 and 1 mM ParSL-3 treated mitochondria (intact or broken) are shown with filled circles (●) and filled triangles (▲), respectively. The specific activity of rat liver mitochondria is 0.44 mU/mg (substrate: serotonin) and 1.56 mU/mg (substrate: 3-AmMePy), respectively.