Table 1.
Prevalence of clinical characteristics, autoantibodies, and serum IFN-α activity in SLE patients stratified by ancestral background.
| European Americans (%) | Hispanic Americans (%) | African Americans (%) | Χ2 | p-value | |
|---|---|---|---|---|---|
| Female | 88.6 | 87.1 | 92.0 | 4.19 | 0.12 |
| Age (yrs mean+/−SD) | 45.5+/−14.1 | 38.4+/−14.2 | 41.9+/−12.4 | - | 3.5 × 10−13 |
| Photosensitivity | 57.2 | 48.4 | 33.9 | 47.36 | 5.2 × 10−11 |
| Discoid Rash | 10.2 | 13.4 | 25.8 | 39.25 | 3.0 × 10−9 |
| Malar Rash | 59.5 | 50.5 | 42.9 | 23.92 | 6.4 × 10−6 |
| Oral Ulcer | 38.4 | 34.4 | 26.6 | 13.24 | 1.3 × 10−3 |
| Serositis | 42.4 | 40.3 | 35.9 | 3.67 | 0.16 |
| Hematologic | 57.9 | 57.0 | 72.1 | 21.36 | 2.3 × 10−5 |
| Immunologic | 78.5 | 80.1 | 82.9 | 2.79 | 0.25 |
| Neurologic | 12.8 | 9.14 | 15.2 | 3.65 | 0.16 |
| Renal Disease | 29.1 | 43.0 | 42.4 | 20.63 | 3.3 × 10−5 |
| Arthritis | 83.3 | 60.8 | 78.6 | 39.20 | 3.1 × 10−9 |
| ANA | 99.0 | 97.3 | 99.2 | 2.71 | 0.27 |
| Anti-dsDNA | 27.3 | 28.5 | 30.2 | 0.78 | 0.68 |
| Anti-Sm | 3.10 | 9.14 | 18.1 | 56.27 | 6.0 × 10−13 |
| Anti-RNP | 9.50 | 21.0 | 45.7 | 156.98 | 8.2 × 10−35 |
| Anti-Ro | 21.7 | 25.3 | 32.8 | 13.60 | 1.1 × 10−3 |
| Anti-La | 6.40 | 9.68 | 8.79 | 2.29 | 0.32 |
| High IFN | 27.7 | 44.1 | 53.5 | 61.97 | 3.5 × 10−14 |
% indicates the percentage of subjects in which the specified disease feature is present, except Age which is reported as a mean years of age at recruitment +/− the standard deviation (SD). ANA = antinuclear antibody test, Χ2 = Chi-square test statistic. P-values are derived from the Chi-square test statistic with two degrees of freedom for all rows, except age which is calculated using one-way ANOVA with a p-value calculated from Fisher’s F value.