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. Author manuscript; available in PMC: 2012 Apr 15.
Published in final edited form as: Biol Psychiatry. 2011 Feb 3;69(8):754–761. doi: 10.1016/j.biopsych.2010.12.015

Figure 2.

Figure 2

Rapid behavioral actions of ketamine in the CUS model require mTOR signaling. On day 21, rapamycin (0.2 nmol, ICV) or DMSO was infused 30 min before ketamine (10 mg/kg, i.p.) or vehicle treatment. The SPT was conducted 1 day (A) and the NSFT 2 days after drug administration. Pre-treatment with rapamycin completely abolished the behavioral actions of ketamine in both SPT (A) and NSFT (B). Values represent mean ± SEM (n = 6 per group; **P < 0.01, ANOVA).