Table II.
K1/2 and ΔV1/2, max for the ATP dose–response curves of V634 mutants
| Channels/mutants | K1/2 | ΔV1/2, max | n |
| mM | mV | ||
| WT CLC-1 | 0.78 ± 0.08 | 76.9 ± 7.4 | 8 |
| V634F | 0.026 ± 0.002 | 61.6 ± 4.9 | 7 |
| V634Y | 0.050 ± 0.004 | 46.6 ± 3.3 | 5 |
| V634W | 0.11 ± 0.01 | 90.7 ± 9.4 | 4 |
| V634C | 0.81 ± 0.06 | 70.8 ± 3.3 | 5 |
| V634S | 1.8 ± 0.3 | 72.9 ± 8.5 | 4 |
| V634D | 7.4 ± 1.5 | 18.5 ± 3.1 | 4 |
| V634G | 13.3 ± 4.0 | 77.8 ± 8.1 | 4 |
| E865D | 0.40 ± 0.09 | 14.2 ± 2.4 | 6 |
| V613A | 2.3 ± 0.3 | 26.3 ± 3.4 | 4 |
| E865D-V634F | 0.089 ± 0.05 | 8.7 ± 2.4 | 4 |
| V613A-V634F | 2.3 ± 0.35 | 62.6 ± 5.4 | 7 |
K1/2 determined from Eq. 1, using ΔV1/2 as the response to ATP inhibition. Means ± SEM are given.