Table 3.
Syndrome | Affected gene(s) | Relative risk of PDAC |
---|---|---|
Familial atypical multiple melanoma and mole syndrome | CDKN2A | 20–34 |
Peutz-Jeghers syndrome | LKB1 | >100 |
Hereditary pancreatitis | PRSS1/SPINK1 | ~90 |
Familial breast cancer | BRCA1/2 | 3–10 |
Lynch syndrome | mismatch repair genes | unknown |