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. 2001 Mar 13;98(6):3519–3524. doi: 10.1073/pnas.061449498

Figure 1.

Figure 1

Structure of the reduced dipeptidomimetic SCL and its blocking activity on recombinant NMDA receptors expressed in amphibian oocytes. (A) Representation of the N-alkylated triamine PS-SCL in which O denotes a defined functionality derived from a single building block and X denotes a mixture of functionalities derived from a mixture of all of the building blocks used to generate the relevant diversity position. (B) Glu- and Gly-activated inward currents through NMDA receptors expressed in oocytes. (C) Block of Glu- and Gly-activated inward currents through NMDA receptors expressed in oocytes after perfusion of a mixture defined with L-isoleucine and benzyl at positions 1 and 2. Holding potential was −80 mV. Glu (200 μM)/Gly (20 μM) and mixture (10 μM) were applied for the duration indicated by the horizontal bars.