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. 2001 Mar 13;98(6):3519–3524. doi: 10.1073/pnas.061449498

Figure 5.

Figure 5

NBTA is a specific blocker of the NMDA receptor. Blocking activity of NBTA (1 μM) on NMDA receptors (A) or GluR1 channels (B). (C) Concentration-inhibition curves for NMDA receptors and GluR1 channels by NBTA (▪), memantine (▴), MK-801 (▾), or phencyclidine (●). (D) Blocking activity of NBTA on wild-type NMDA receptors [NR1/NR2A (■)] − IC50 = 80 ± 10 nM (n = 6), and nH = 0.8 and indicated mutants: N616R/NR2A (⧫) − IC50 = 22,000 ± 1,320 nM (n = 5), nH = 0.8; N616Q/NR2A (○) − IC50 = 240 ± 20 nM (n = 4), nH = 0.8; NR1/W606L (▾) − IC50 = 380 ± 32 nM (n = 5), nH = 0.8; NR1/N614G (▵) − IC50 = 95 ± 11 nM (n = 5), nH = 0.9; NR1/N615G (□) − IC50 = 72 ± 8 nM (n = 5), nH = 0.9; NR1/S616G (▴) − IC50 = 98 ± 9 nM (n = 5), nH = 0.8; and N616Q/N614G (●) − IC50 = 244 ± 23 nM (n = 5), nH = 0.8. Currents were elicited by 200 μM Glu/20 μM Gly at a holding potential of −80 mV.