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. 2001 Mar 13;98(6):3519–3524. doi: 10.1073/pnas.061449498

Figure 6.

Figure 6

NBTA is a reversible open-channel blocker of the NMDA receptor. (A) Concentration-response curve of Glu (with 20 μM Gly) evoked currents from NMDA receptors in the absence (■) or presence (▴) of 0.2 μM NBTA (n = 4 oocytes). (B) Concentration-response curve for Gly (with 200 μM Glu) in the absence (■) or presence (▴) of 0.2 μM NBTA (n = 4 oocytes). (C) Voltage dependence of NMDA-receptor block by NBTA. Current-voltage characteristics of responses evoked by 200 μM Glu/20 μM Gly in the absence or presence of 1 μM NBTA. The voltage-ramp protocols were performed when agonist-evoked inward currents reached a steady state. (D) Use dependence of NMDA-receptor block by NBTA. Sequentially perfused oocytes by using agonist/coagonist pulses (200 μM Glu/20 μM Gly) without and with NBTA (0.1 μM) followed by pulses of agonist/coagonist alone. Pulse duration is indicated by the horizontal bar. Evoked currents were measured at −80 mV.